Duplication of centrosomes once per cell cycle is essential for bipolar spindle formation and genome maintenance and is controlled in part by cyclin-dependent kinases (Cdks). Our study identifies Sfi1. a conserved component of centrosomes. as the first Cdk substrate required to restrict centrosome duplication to once per cell cycle. https://www.chiggate.com/western-wanted-reward-sign-cutouts-4-pack-sale/